Subchronic toxicity study in rats fed gum karaya.

Abstract

Gum karaya was given to groups of 15 rats of each sex at levels of 0 (control), 0.2, 1 or 5% (w/w) in the diet for 13 wk. An increase in faecal bulk was seen in all treated groups throughout the study. There was a decrease in weight-gain at the highest dietary level (significant only in the females), which was associated with a marginal reduction in food-conversion efficiency. Males given 1 or 5% drank more than the controls and a transient increase in water intake was seen in females given the highest level. The no-untoward-effect level from this study was 5% (w/w) of the diet, providing a mean intake of about 4 g karaya gum/kg body weight/day.

• Authors: P J Taupin, D M Anderson
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 20 Issue 5 Pg. 513-7 (Oct 1982) ISSN: 0278-6915 [Print] England
• PMID: 6890505 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Polysaccharides
• Karaya Gum

Topics

• Animals
• Body Weight (drug effects)
• Diet
• Drinking Behavior (drug effects)
• Feeding Behavior (drug effects)
• Female
• Karaya Gum (toxicity)
• Male
• Organ Size (drug effects)
• Polysaccharides (toxicity)
• Rats
• Rats, Inbred Strains