Tumorigenic action of repeated subcutaneous administration of N-methyl-N-formylhydrazine in mice.

Abstract

N-Methyl-N-formylhydrazine (MFH), an ingredient of the edible false morel mushroom, was administered to Swiss mice as 40 weekly subcutaneous injections at 20 micrograms/g body weight for females and 10 micrograms/g body weight for males. The treatments gave rise to statistically significant incidences of lung tumors: 56% in females and 40% in males. The administration of the chemical resulted in no detectable carcinogenic effect in other organs. The findings are discussed in light of the results from earlier studies with this compound.

• Authors: B Toth, K Patil
• Journal: Neoplasma (Neoplasma) Vol. 30 Issue 4 Pg. 437-41 ( 1983) ISSN: 0028-2685 [Print] Slovakia
• PMID: 6888608 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Methylhydrazines
• N-methyl-N-formylhydrazine
• Monomethylhydrazine

Topics

• Animals
• Female
• Injections, Subcutaneous
• Lung Neoplasms (chemically induced)
• Male
• Methylhydrazines (administration & dosage)
• Mice
• Mice, Inbred Strains
• Monomethylhydrazine (administration & dosage, analogs & derivatives)
• Neoplasms, Experimental (chemically induced)
• Time Factors