Aldosterone metabolites and possible aldosterone precursors in hypertension.

Abstract

The value of the urine tests: free aldosterone, aldosterone-18-glucuronide, tetrahydroaldosterone 18-hydroxycorticosterone and 18-hydroxydeoxycorticosterone in distinguishing primary aldosteronism from essential hypertension was studied in patients with typical and atypical primary aldosteronism and in patients with essential hypertension. The discriminating function of the tetrahydroaldosterone determination was the best, followed by 18-hydroxycorticosterone, free aldosterone and aldosterone-18-glucuronide. The measurement of 18-hydroxydeoxycorticosterone was without distinguishing value. Three cases with hypertension, adrenal adenoma, elevated 18-hydroxycorticosterone but normal aldosterone values were observed. In longitudinal studies the excretions of aldosterone, aldosterone metabolites and possible precursors periodically varied independently of each other. Determinations of urine aldosterone, aldosterone metabolites, 18-hydroxycorticosterone and 18-hydroxydeoxycorticosterone were not applicable for differential diagnosis of the adenoma and hyperplasia forms of primary aldosteronism.

• Authors: P Vecsei, S Abdelhamid, G V Mittelstädt, K Lichtwald, D Haack, S Lewicka
• Journal: Journal of steroid biochemistry (J Steroid Biochem) Vol. 19 Issue 1A Pg. 345-51 (Jul 1983) ISSN: 0022-4731 [Print] England
• PMID: 6887870 (Publication Type: Journal Article)

Chemical References

• Antigen-Antibody Complex
• Aldosterone

Topics

• Adenoma (metabolism)
• Adrenal Gland Neoplasms (metabolism)
• Adrenocortical Hyperfunction (metabolism)
• Aldosterone (metabolism, urine)
• Antigen-Antibody Complex
• Cross Reactions
• Humans
• Hyperaldosteronism (metabolism)
• Hypertension (metabolism)