Induction of angiogenic tumors in the duodenum of female Donryu rats by continuous oral administration of N-isobutyl-N-nitrosourea.

Abstract

Four groups of female Donryu rats were continuously given 400, 200, 100 or 0 ppm N-isobutyl-N-nitrosourea (iso-BNU) in their drinking water, and were examined for the development of tumors. The incidence of digestive tract tumors was 25/28 (89%), 14/24 (58%), 6/25 (24%) and 0/17 (0%), in the 400, 200, 100 and 0 ppm groups, respectively. The predominant type of digestive tract tumor was angiogenic, and a few were of the epithelial type. A dose-effect relationship was clearly demonstrated not only in the incidence of digestive tract tumors but also in the average survival period of rats with these tumors.

• Authors: T Ogiu, C Matsuoka, K Furuta, M Takeuchi, A Maekawa, M Nakadate, S Odashima
• Journal: Gan (Gan) Vol. 74 Issue 3 Pg. 342-50 (Jun 1983) ISSN: 0016-450X [Print] Japan
• PMID: 6884692 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Nitrosourea Compounds
• N-isobutyl-N-nitrosourea

Topics

• Administration, Oral
• Animals
• Carcinogens
• Dose-Response Relationship, Drug
• Duodenal Neoplasms (chemically induced, pathology)
• Female
• Hemangioendothelioma (chemically induced)
• Mammary Neoplasms, Experimental (chemically induced)
• Neoplasms, Experimental (chemically induced)
• Neoplasms, Vascular Tissue (chemically induced)
• Nitrosourea Compounds (toxicity)
• Rats
• Rats, Inbred Strains
• Structure-Activity Relationship