[Antitumor activity of chlorella extract, PCM-4, by oral administration].

Abstract

The antitumor activity of a water-soluble substance extracted from Chlorella regulararis S-50, PCM-4, against murine transplanted tumors was investigated. PCM-4 is composed of sugar (25.7%), protein (51.5%) and nucleic acid (18.7%). By oral administration of PCM-4, both the growth of Sarcoma 180 and Meth A, subcutaneously implanted into mice, and ascites hepatoma AH 44 and AH 41C, intravenously implanted into rat, was inhibited. PCM-4 also showed antitumor activity against Sarcoma 180 and Meth A by intraperitoneal administration. The finding that PCM-4 has no direct growth-inhibition effect on tumor cells in vitro suggests that the antitumor activity of PCM-4 be elicited from the host-mediated response system.

• Authors: K Nomoto, T Yokokura, H Satoh, M Mutai
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 10 Issue 3 Pg. 781-5 (Mar 1983) ISSN: 0385-0684 [Print] Japan
• PMID: 6881997 (Publication Type: English Abstract, Journal Article)

Chemical References

• PCM 4
• Plant Extracts

Topics

• Administration, Oral
• Animals
• Cell Division (drug effects)
• Chlorella
• Liver Neoplasms, Experimental (drug therapy)
• Mice
• Mice, Inbred ICR
• Plant Extracts (administration & dosage, analysis, therapeutic use)
• Rats
• Rats, Inbred Strains
• Sarcoma 180 (drug therapy)