Polymorphic CC57W mice
rhabdomyosarcoma MC-53, after selection for
malignancy, was investigated during the
transplantation to subcutaneous connective tissue (SCT) and the eye anterior chamber (EAC). SCT and EAC transplants appeared to be equal both morphologically and ultrastructurally. Relationship between M- and H-forms of LDH, and the karyotype structure of
tumor cell populations were invariably similar in SCT and EAC. However, after EAC proliferation, in contrast to SCT proliferation, transplantability of
tumor rhabdomyoblasts decreased, which may be associated with a decrease in proliferative activity of
tumor cells in the EAC. Our data allow to suppose that mouse
rhabdomyosarcoma MC-53 cells, during selection for
malignancy, lost its capacity of differentiating and normalizing in EAC, unlike the previously investigated
rhabdomyosarcomas MC-62, MC-III and
A-7. These results may be explained by the fast progression of this
tumor line. It is obvious that capacity of
tumor cells of differentiating and normalizing during the EAC proliferation may depend on the
tumor histological type, on the retention capacity of
tumor cell elements of differentiating and on the stage of progression.