Temocillin elimination in patients with varying degrees of renal failure.

Abstract

Temocillin is a new penicillin combining activity against Gram-positive organisms, beta-lactamase stability and an exceptionally long half-life. In patients with normal renal function the half-life was approximately 4-6 h and this increased to 30 h in patients with severe renal failure. It is suggested that unlike other penicillins this compound may give adequate antibacterial concentration with once daily dosing in subjects with normal renal function; this will certainly require reduction in subjects with severely impaired renal function.

• Authors: N Wright, R Wise, J D Price
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 11 Issue 5 Pg. 481-4 (May 1983) ISSN: 0305-7453 [Print] England
• PMID: 6874633 (Publication Type: Journal Article)

Chemical References

• Penicillins
• temocillin

Topics

• Half-Life
• Humans
• Kidney Diseases (metabolism)
• Kinetics
• Penicillins (metabolism)