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Chemically induced congenital thymic dysgenesis in the rat: a model of the DiGeorge syndrome.

Abstract
The DiGeorge syndrome, a variable complex of thymic aplasia, congenital heart disease, hypoparathyroidism, and anomalies of the face and neck, is thought to result from exposure to teratogenic agents. A group of congenital defects closely resembling this syndrome can be produced in newborn rats by the administration of the fat-soluble zinc chelating agent WIN 18,446, a bis-dichloroacetylamine. This drug, nontoxic to adult animals, is a powerful teratogen when administered to pregnant rats during days 9-12 of the 21-day gestation period. Our animal data suggest that the human syndrome results from exposure in utero to agents like WIN 18,446, which damage the fetus during a critical period of organogenesis.
AuthorsG Oster, K H Kilburn, F P Siegal
JournalClinical immunology and immunopathology (Clin Immunol Immunopathol) Vol. 28 Issue 1 Pg. 128-34 (Jul 1983) ISSN: 0090-1229 [Print] United States
PMID6872357 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Diamines
  • N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine
Topics
  • Animals
  • DiGeorge Syndrome (chemically induced, embryology, immunology)
  • Diamines (administration & dosage)
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Immunologic Deficiency Syndromes (chemically induced)
  • Pregnancy
  • Rats
  • Thymus Gland (embryology, pathology)
  • Time Factors

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