Abstract |
The DiGeorge syndrome, a variable complex of thymic aplasia, congenital heart disease, hypoparathyroidism, and anomalies of the face and neck, is thought to result from exposure to teratogenic agents. A group of congenital defects closely resembling this syndrome can be produced in newborn rats by the administration of the fat-soluble zinc chelating agent WIN 18,446, a bis-dichloroacetylamine. This drug, nontoxic to adult animals, is a powerful teratogen when administered to pregnant rats during days 9-12 of the 21-day gestation period. Our animal data suggest that the human syndrome results from exposure in utero to agents like WIN 18,446, which damage the fetus during a critical period of organogenesis.
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Authors | G Oster, K H Kilburn, F P Siegal |
Journal | Clinical immunology and immunopathology
(Clin Immunol Immunopathol)
Vol. 28
Issue 1
Pg. 128-34
(Jul 1983)
ISSN: 0090-1229 [Print] United States |
PMID | 6872357
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Diamines
- N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine
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Topics |
- Animals
- DiGeorge Syndrome
(chemically induced, embryology, immunology)
- Diamines
(administration & dosage)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Female
- Humans
- Immunologic Deficiency Syndromes
(chemically induced)
- Pregnancy
- Rats
- Thymus Gland
(embryology, pathology)
- Time Factors
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