Tick (Ixodes holocyclus) paralysis in the dog--induction of immunity by injection of toxin.

Abstract

Three beagle dogs were immunised against the paralysing effects of holocyclotoxin, using toxic extracts derived from salivary glands of the Australian paralysis tick, Ixodes holocyclus. Upon subsequent challenge with four ED50's of toxin the animals were completely immune, whereas during the early stages 2 of 3 dogs became paralysed after injection with 0.5 ED50. Three immunised beagles, on which 15 I. holocyclus ticks had fed, showed no symptoms but a control beagle became paralysed after 4 I. holocyclus females fed on it. Treatment was instituted immediately upon the onset of clinical signs and the dog recovered uneventfully.

• Authors: I G Wright, B F Stone, A L Neish
• Journal: Australian veterinary journal (Aust Vet J) Vol. 60 Issue 3 Pg. 69-70 (Mar 1983) ISSN: 0005-0423 [Print] England
• PMID: 6870708 (Publication Type: Journal Article)

Chemical References

• Antivenins
• Arthropod Venoms
• Vaccines
• holocyclotoxin

Topics

• Animals
• Antibody Formation
• Antivenins (analysis)
• Arthropod Venoms (immunology)
• Dog Diseases (immunology)
• Dogs
• Female
• Tick Paralysis (immunology, veterinary)
• Tick Toxicoses (veterinary)
• Ticks (immunology)
• Vaccination (methods, veterinary)
• Vaccines (immunology)