A case of IgA nephropathy with an unusual response to corticosteroid and immunosuppressive therapy.

We report a case of IgA nephropathy that presented with nephrotic syndrome without hematuria. Renal biopsy revealed typical features of IgA nephropathy on light microscopy, immunofluorescence microscopy, and electron microscopy. A dramatic response occurred on corticosteroid and immunosuppressive therapy, characterized by clearance of proteinuria and a fall of serum IgA level to normal. The absence of hematuria and a response to therapy are distinctly unusual features of IgA nephropathy. This case represents a variant of IgA nephropathy associated with a nephrotic syndrome that resembles nephrotic syndrome with minimal change lesion in its responsiveness to immunosuppressive therapy.
AuthorsK Abreo, S F Wen
JournalAmerican journal of kidney diseases : the official journal of the National Kidney Foundation (Am J Kidney Dis) Vol. 3 Issue 1 Pg. 54-7 (Jul 1983) ISSN: 0272-6386 [Print] UNITED STATES
PMID6869370 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunoglobulin A
  • Cyclophosphamide
  • Prednisone
  • Adult
  • Cyclophosphamide (administration & dosage, therapeutic use)
  • Drug Therapy, Combination
  • Glomerulonephritis (complications, drug therapy, immunology)
  • Humans
  • Immunoglobulin A (immunology)
  • Male
  • Nephrotic Syndrome (etiology)
  • Prednisone (administration & dosage, therapeutic use)

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