[Effect of stroma-free hemoglobin solutions in hemorrhagic shock--a review of animal experimental results].

Abstract

On a potential blood substitute--the stroma-free hemoglobin solution--is pointed out by animal experimental results of the bibliography. The increase of the oxygen capacity and the improvement of the microcirculation enable to guarantee the oxygen supply of hypoxic tissues by the hemoglobin solution. The arterial mean pressure, the cardiac output, and the heart rate in hemorrhagic shock could become normalized by infusion of hemoglobin solution. The short half-life and the elevated oxygen affinity were given as disadvantageous.

• Authors: H G Birkigt
• Journal: Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR (Z Exp Chir Transplant Kunstliche Organe) Vol. 16 Issue 2 Pg. 103-8 ( 1983) ISSN: 0232-7295 [Print] Germany
• Vernacular Title: Die Wirkung stromafreier Hämoglobinlösungen im hämorrhagischen Schock--eine Ubersicht tierexperimenteller Ergebnisse.
• PMID: 6868726 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hemoglobins
• Plasma Substitutes
• hemoglobin, stroma free
• Oxygen

Topics

• Animals
• Hemodynamics (drug effects)
• Hemoglobins (therapeutic use)
• Kidney (drug effects)
• Kidney Function Tests
• Microcirculation (drug effects)
• Oxygen (blood)
• Plasma Substitutes (therapeutic use)
• Shock, Hemorrhagic (blood, drug therapy)