Activity of 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)aminophenoxyacetate (NSC 294859) on experimental animal tumor and leukemia systems.

Abstract

3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)amino-phenoxyacetate, a modified steroidal alkylating agent, is active in the treatment of colon 26 tumor, B16 melanoma and P388 leukemia.

• Authors: P Catsoulacos
• Journal: Oncology (Oncology) Vol. 40 Issue 4 Pg. 290-2 ( 1983) ISSN: 0030-2414 [Print] Switzerland
• PMID: 6866424 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Nitrogen Mustard Compounds
• NSC 294859

Topics

• Animals
• Antineoplastic Agents (administration & dosage)
• Colonic Neoplasms (drug therapy, pathology)
• Dose-Response Relationship, Drug
• Female
• Leukemia P388 (drug therapy, pathology)
• Leukemia, Experimental (drug therapy)
• Male
• Melanoma (drug therapy, pathology)
• Mice
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy)
• Nitrogen Mustard Compounds (administration & dosage)
• Time Factors