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Activity of 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)aminophenoxyacetate (NSC 294859) on experimental animal tumor and leukemia systems.

Abstract
3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)amino-phenoxyacetate, a modified steroidal alkylating agent, is active in the treatment of colon 26 tumor, B16 melanoma and P388 leukemia.
AuthorsP Catsoulacos
JournalOncology (Oncology) Vol. 40 Issue 4 Pg. 290-2 ( 1983) ISSN: 0030-2414 [Print] SWITZERLAND
PMID6866424 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Nitrogen Mustard Compounds
  • NSC 294859
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage)
  • Colonic Neoplasms (drug therapy, pathology)
  • Dose-Response Relationship, Drug
  • Female
  • Leukemia P388 (drug therapy, pathology)
  • Leukemia, Experimental (drug therapy)
  • Male
  • Melanoma (drug therapy, pathology)
  • Mice
  • Neoplasm Transplantation
  • Neoplasms, Experimental (drug therapy)
  • Nitrogen Mustard Compounds (administration & dosage)
  • Time Factors

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