Neuroleptanalgesia in the rabbit.

Abstract

The efficacy of the neuroleptanalgesic combinations of fentanyl-fluanisone with diazepam; and etorphine-methotrimeprazine, either alone, or with diazepam, was investigated in the rabbit. The effects of these drugs on some cardiovascular variables were studied in chronically catheterized rabbits. Fentanyl-fluanisone and diazepam produced good surgical anaesthesia. Although respiratory depression occurred, this had little effect on blood gas values. In contrast, etorphine-methotrimeprazine and diazepam produced severe respiratory depression with consequent hypercapnia and acidosis.

• Authors: P A Flecknell, M John, M Mitchell, C Shurey, S Simpkin
• Journal: Laboratory animals (Lab Anim) Vol. 17 Issue 2 Pg. 104-9 (Apr 1983) ISSN: 0023-6772 [Print] England
• PMID: 6865315 (Publication Type: Journal Article)

Chemical References

• Butyrophenones
• Drug Combinations
• Morphinans
• fluanisone
• Etorphine
• Methotrimeprazine
• Diazepam
• Fentanyl

Topics

• Acidosis (chemically induced)
• Animals
• Butyrophenones (pharmacology)
• Diazepam (pharmacology)
• Drug Combinations
• Etorphine (adverse effects, pharmacology)
• Fentanyl (pharmacology)
• Hypercapnia (chemically induced)
• Methotrimeprazine (adverse effects, pharmacology)
• Morphinans (pharmacology)
• Neuroleptanalgesia (veterinary)
• Rabbits
• Respiration (drug effects)
• Time Factors