Effect of conalbumin on phytomitogen stimulation and E-rosette formation of human peripheral lymphocytes in normal subjects.
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| Abstract |
An immunological in vitro study was carried out on conalbumin, an iron binding protein structurally similar to lactoferrin, which is a well-known bacterial inhibitor in human milk. Conalbumin itself has been proved to have bacteriostatic activity against a broad spectrum of bacteria responsible for gastrointestinal infections. The activity of conalbumin on the in vitro response to PHA, PWM and Con A and on the E-rosette formation ability of peripheral lymphocytes of 10 normal subjects was studied. The results showed that conalbumin did not affect the lymphocytes' E-rosette formation ability and did not induce blastic transformation of lymphocytes. However, conalbumin was able to produce a significant increase in the in vitro response of lymphocytes to PHA and PWM, suggesting an action on both T and B lymphocytes.
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| Authors | G Mantovani, A Puddu, A L Leone, S Tognella, G S Del Giacco |
| Journal | International journal of tissue reactions (Int J Tissue React) Vol. 5 Issue 1 Pg. 107-11 ( 1983) ISSN: 0250-0868 [Print] Switzerland |
| PMID | 6862784 (Publication Type: Journal Article) |
| Chemical References |
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