[Clinico-pharmacological study of neurotropic agents in neurogenic diseases of the cardiovascular system and stomach].

Abstract

It has been established in experiments that as visceral pathology arising during excess exposures advances, the deficiency of energy resources develops in the tissues of damaged organs. Application of the agents that normalize the function of the sympathetic nervous system (L-DOPA) and stimulate energy formation processes (ethimizol) accelerated reparative processes in damaged stomach and myocardium. Application of L-DOPA and ethimizol to the treatment of peptic ulcer patients produced a good therapeutic effect--an increase in the creatine phosphate content in the gastric mucosa and removal of the niche symptom in 80% of cases.

• Authors: I S Zavodskaia, E V Moreva, E A Migas, V V Bul'on, V P Novikov
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1983 May-Jun Vol. 46 Issue 3 Pg. 17-20 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Kliniko-farmakologicheskoe izuchenie nekotorykh neĭrotropnykh sredstv pri neĭrogennykh zabolevaniiakh serdechno-sosudistoĭ sistemy i zheludka.
• PMID: 6861984 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Levodopa
• Etimizol

Topics

• Animals
• Cardiovascular Diseases (drug therapy, metabolism)
• Drug Evaluation
• Drug Evaluation, Preclinical
• Energy Metabolism (drug effects)
• Etimizol (pharmacology, therapeutic use)
• Humans
• Levodopa (pharmacology, therapeutic use)
• Male
• Rabbits
• Rats
• Stomach Ulcer (drug therapy, metabolism)
• Sympathetic Nervous System (drug effects)