[Lipolytic activity in blood plasma of patients with ischemic heart disease after administration of heparin on an empty stomach and with simultaneous fatty loading].

Abstract

Effect of heparin on the lipoprotein lipase activity was studied after its administration into fasting and fat loaded patients with heart ischemic disease, exhibiting various lipoprotein spectrum of blood. Heparin activated more distinctly the lipolytic enzymes in the patients kept on fatty diet as compared with the fasting patients. The difference was maximal in the patients with the IIa type of hypolipoproteinemia and minimal--in the patients with the IV type of the disease. The hypotriglyceridemic effect of heparin was found in all the groups examined; however, the least decrease in the triglyceride content occurred in the IV type of hypolipoproteinemia. These data demonstrate the relative deficiency of lipoprotein lipolysis in the type of hypolipoproteinemia studied.

• Authors: N G Nikul'cheva, I B Soliternova, I V Krivoruchenko
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1983 Mar-Apr Vol. 29 Issue 2 Pg. 35-40 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Lipoliticheskaia aktivnost' plazmy krovi bol'nykh ishemicheskoĭ bolezn'iu serdtsa pri vvedenii geparina natoshchak i na fone zhirovoĭ nagruzki.
• PMID: 6858033 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dietary Fats
• Lipoproteins
• Triglycerides
• Heparin

Topics

• Adult
• Coronary Disease (blood)
• Dietary Fats
• Heparin
• Humans
• Kinetics
• Lipolysis
• Lipoproteins (blood)
• Male
• Middle Aged
• Triglycerides (blood)