Effect of organo-tellurium compounds on the enzymatic alterations in rats.

Abstract

An attempt has been made to correlate early toxicity of organo-tellurium (Te) compounds with enzymic alterations in liver, kidney, brain and serum at 1 and 3 days following single i.p. injections of bis-(tetraphenyl phosphonium) tetracyanato-bis-p-methoxy p-phenyl tellurate(IV) (TTMT) and bis-(tetraheptyl ammonium) tetraiodocyclopentane tellurate(IV) (TACT). These compounds, at 2 and 1 mg Te/kg body weight as TTMT and TACT, respectively, produced cholinergic signs and caused death within 3 days. Administration at maximum tolerable doses of 0.5 mg and 0.1 mg Te/kg body weight as TTMT and TACT, respectively, resulted in significant reduction of acetylcholine esterase (AChE) and monoamine oxidase (MAO) in serum and brain and by a significant decrease in hepatic glutathione and in glutathione-S-transferase (GST) and alkaline phosphatase in liver and kidney.

• Authors: R C Srivastava, R Srivastava, T N Srivastava, S P Jain
• Journal: Toxicology letters (Toxicol Lett) Vol. 16 Issue 3-4 Pg. 311-6 (May 1983) ISSN: 0378-4274 [Print] Netherlands
• PMID: 6857726 (Publication Type: Journal Article)

Chemical References

• Cholinesterase Inhibitors
• Enzymes
• Monoamine Oxidase Inhibitors
• bis(tetraheptylammonium)tetraiodocyclopentane tellurate(IV)
• bis(tetraphenylphosphonium)tetracyanato-bis-4-methoxy-4-phenyltellurate(IV)
• Glutathione Transferase
• Acetylcholinesterase
• Alkaline Phosphatase
• Glutathione
• Tellurium

Topics

• Acetylcholinesterase
• Alkaline Phosphatase (metabolism)
• Animals
• Brain (enzymology)
• Cholinesterase Inhibitors
• Enzymes (blood, metabolism)
• Female
• Glutathione (metabolism)
• Glutathione Transferase (antagonists & inhibitors)
• Kidney (enzymology)
• Liver (enzymology)
• Monoamine Oxidase Inhibitors
• Rats
• Tellurium (toxicity)