Identification of three indolic compounds in a pigmented-melanoma cell-culture supernatant by gas chromatography-mass spectrometry.

Abstract

In the supernatant of melanoma cell culture SK mel 25 three indolic compounds - 5-hydroxy-6-methoxyindole, 5-hydroxy-6-methoxyindolyl-2-carboxylic, and 6-hydroxy-5-methoxyindolyl-2-carboxylic acids - have been identified. The supernatants were extracted with ethyl acetate, derivatized, and analyzed by gas chromatography-mass spectrometry. The significance of this finding is discussed.

• Authors: S Pavel, F A Muskiet, L de Ley, T H The, W van der Slik
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 105 Issue 3 Pg. 275-9 ( 1983) ISSN: 0171-5216 [Print] Germany
• PMID: 6853590 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Indoles
• 5-hydroxy-6-methoxyindole
• 5-hydroxy-6-methoxy-2-indolylcarboxylic acid
• 6-hydroxy-5-methoxy-2-indolylcarboxylic acid

Topics

• Cells, Cultured
• Gas Chromatography-Mass Spectrometry
• Humans
• Indoles (analysis)
• Melanoma (analysis)
• Skin Neoplasms (analysis)