Effect of D-glucosamine on the content and synthesis of UDP-sugars and plasma membrane associated carbohydrates in chicken liver and hepatoma Mc-29.

Abstract

1. Comparative studies on the effect of D-glucosamine on the synthesis of UDP-sugars and on the incorporation rate of [14C]glucose into neutral sugars, sialic acid and glucosamine isolated from chicken liver and hepatoma Mc-29 plasma membranes have been carried out. 2. The influence of D-glucosamine on the activity of microsomal UDP-N-acetylglucosamine: glycoprotein N-acetylglucosaminyltransferase to lipid (dolichol monophosphate) and to protein acceptor was studied too. 3. It has been shown that D-glucosamine provokes alterations in the content and synthesis of UDP-sugars and it is an inhibitor of the glycosylation processes. An inhibitory effect of this sugar analog on the N-acetylglycosaminyltransferase has been established.

• Authors: H Chelibonova-Lorer, E Gavazova, S Ivanov, M Antonova
• Journal: The International journal of biochemistry (Int J Biochem) Vol. 15 Issue 4 Pg. 559-64 ( 1983) ISSN: 0020-711X [Print] England
• PMID: 6852355 (Publication Type: Journal Article)

Chemical References

• Carbon Radioisotopes
• Sialic Acids
• Uridine Diphosphate Sugars
• Glucose
• Glucosamine

Topics

• Animals
• Carbohydrate Metabolism
• Carbon Radioisotopes
• Cell Membrane (metabolism)
• Glucosamine (pharmacology)
• Glucose (metabolism)
• Kinetics
• Liver (drug effects, metabolism)
• Liver Neoplasms, Experimental (metabolism)
• Sialic Acids (biosynthesis)
• Uridine Diphosphate Sugars (metabolism)