[Potential use of the antiserotonin preparation cyproheptadine (peritol) in Itsenko-Cushing disease].

Abstract

Experiments on male rats have shown that the inhibitory effect of peritol on the hypothalamohypophyseal-adrenal system (HHAS) is determined both by its influence on the regulatory mechanisms of the CNS and direct action on secretion and, possibly, synthesis of steroids. The degree of the antiserotonin and the HHAS-inhibiting effects depends on the frequency of drug administrations rather than on its dose. The experimental studies made it possible to successfully apply peritol to the treatment of inpatients suffering from Icenko-Cushing's disease. Almost 60% of the inpatients manifested a remission, which was confirmed by the reduced blood content of ACTH, hydrocortisone and aldosterone.

• Authors: G V Valueva, E V Luchitskiĭ, A A Iakovlev
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1983 Mar-Apr Vol. 46 Issue 2 Pg. 50-3 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vozmozhnosti ispol'zovaniia antiserotoninovogo preparata tsiprogeptadina (peritola) pri bolezni Itsenko-Kushinga.
• PMID: 6852218 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hormones
• Cyproheptadine

Topics

• Adolescent
• Adult
• Animals
• Cushing Syndrome (blood, drug therapy)
• Cyproheptadine (administration & dosage, therapeutic use)
• Drug Evaluation
• Drug Evaluation, Preclinical
• Female
• Hormones (blood)
• Humans
• Male
• Middle Aged
• Rats
• Rats, Inbred Strains
• Time Factors