Comparison of guanadrel and guanethidine efficacy and side effects.

Abstract

Eighteen patients with essential hypertension uncontrolled by hydrochlorothiazide alone were randomly assigned to receive additional therapy with either guanadrel sulfate or guanethidine sulfate. The frequencies of morning orthostatic faintness, other orthostatic faintness, and diarrhea were twice as high in eight patients treated with guanethidine as in ten patients treated with guanadrel in a six-month comparison. The two drugs reduced blood pressure about equally well. In light of the efficacy without severe side effects, guanadrel may be an agent for step II therapy of hypertension.

• Authors: S H Malinow
• Journal: Clinical therapeutics (Clin Ther) Vol. 5 Issue 3 Pg. 284-9 ( 1983) ISSN: 0149-2918 [Print] United States
• PMID: 6850722 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Antihypertensive Agents
• Guanidines
• guanadrel
• Guanethidine

Topics

• Adult
• Antihypertensive Agents (adverse effects, therapeutic use)
• Blood Pressure (drug effects)
• Diarrhea (chemically induced)
• Guanethidine (adverse effects, therapeutic use)
• Guanidines (adverse effects, therapeutic use)
• Humans
• Hypertension (drug therapy)
• Pulse (drug effects)
• Syncope (chemically induced)