Abstract |
The tumor-initiating activities of dibenz[a,c]anthracene (DBA) and of the related trans-1,2-, 3,4- and 10,11-dihydrodiols have been examined on mouse skin subsequently promoted with 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The 1,2- and 10,11-dihydrodiols were active and were more active than equivalent doses of either the parent hydrocarbon or the 3,4-dihydrodiol. The data are discussed in relation to possible mechanisms that may be involved in the metabolic activation of DBA.
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Authors | I Chouroulinkov, H Coulomb, A D MacNicoll, P L Grover, P Sims |
Journal | Cancer letters
(Cancer Lett)
Vol. 19
Issue 1
Pg. 21-6
(May 1983)
ISSN: 0304-3835 [Print] Ireland |
PMID | 6850567
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Benz(a)Anthracenes
- Phorbols
- benzotriphenylene
- Tetradecanoylphorbol Acetate
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Topics |
- Animals
- Benz(a)Anthracenes
(toxicity)
- Female
- Mice
- Neoplasms, Experimental
(chemically induced)
- Phorbols
(pharmacology)
- Skin Neoplasms
(chemically induced)
- Structure-Activity Relationship
- Tetradecanoylphorbol Acetate
(pharmacology)
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