Tumor induction by a single subcutaneous injection of 1-butyl-1-nitrosourea or 1-butylurea in newborn mice.

Abstract

A subcutaneous injection of 1-butyl-1-nitrosourea (BNU) at the maximum tolerated dose (333 mg/kg body wt.) to newborn CDF1 mice induced adenocarcinoma and adenoma of the lung, adenoma of the liver, thymic or non-thymic lymphoma and neurinoma of the acusticus nerve; the total incidence of tumors was statistically significant as compared with that of control. However, in the 1-butylurea (BU) mice, one adenoma of the lung was induced in a male mouse; the total incidence of tumor was comparable to that of control.

• Authors: K Fujii, K Nomoto
• Journal: Cancer letters (Cancer Lett) Vol. 18 Issue 3 Pg. 321-8 (Apr 1983) ISSN: 0304-3835 [Print] Ireland
• PMID: 6850564 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Nitrosourea Compounds
• N-nitrosobutylurea
• Urea
• butylurea

Topics

• Adenocarcinoma (chemically induced)
• Adenoma (chemically induced)
• Animals
• Animals, Newborn
• Carcinogens (toxicity)
• Female
• Injections, Subcutaneous
• Liver Neoplasms (chemically induced)
• Lung Neoplasms (chemically induced)
• Lymphoma (chemically induced)
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred DBA
• Neoplasms, Multiple Primary (chemically induced)
• Neuroma, Acoustic (chemically induced)
• Nitrosourea Compounds (toxicity)
• Thymus Neoplasms (chemically induced)
• Urea (analogs & derivatives, toxicity)