Abstract |
In twenty patients with primary congestive cardiomyopathy (COCM) the patterns of accumulation and washout of the fatty acid analogue [17-123I] iodoheptadecanoic acid (I-123 HA) were studied. In contrast to patients with ischemic heart disease, where reduced I-123 HA accumulation was correlated with stenosis of the main coronary arteries, thus usually involving larger wall segments, the patients with COCM concentrated I-123 HA heterogeneously in small spotty segments throughout the entire left-ventricular myocardium. The regional washout half-times varied between 15.1 and 116.2 min. It seems that in patients with severe COCM the elimination half-times are more prolonged than in early stages of the disease. There was no correlation between the regional uptake and the elimination half-times. Sequential myocardial imaging with I-123 HA appears useful for noninvasively diagnosis of COCM.
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Authors | A Höck, C Freundlieb, K Vyska, B Lösse, R Erbel, L E Feinendegen |
Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 24
Issue 1
Pg. 22-8
(Jan 1983)
ISSN: 0161-5505 [Print] United States |
PMID | 6848699
(Publication Type: Journal Article)
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Chemical References |
- Fatty Acids
- Iodine Radioisotopes
- 17-iodoheptadecanoic acid
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Topics |
- Cardiomyopathies
(diagnostic imaging, metabolism)
- Coronary Disease
(diagnostic imaging)
- Diastole
- Fatty Acids
(metabolism)
- Half-Life
- Heart
(diagnostic imaging)
- Heart Septum
(metabolism)
- Heart Ventricles
(diagnostic imaging, metabolism, physiopathology)
- Humans
- Iodine Radioisotopes
- Myocardium
(metabolism)
- Radionuclide Imaging
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