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Myocardial imaging and metabolic studies with [17-123I]iodoheptadecanoic acid in patients with idiopathic congestive cardiomyopathy.

Abstract
In twenty patients with primary congestive cardiomyopathy (COCM) the patterns of accumulation and washout of the fatty acid analogue [17-123I]iodoheptadecanoic acid (I-123 HA) were studied. In contrast to patients with ischemic heart disease, where reduced I-123 HA accumulation was correlated with stenosis of the main coronary arteries, thus usually involving larger wall segments, the patients with COCM concentrated I-123 HA heterogeneously in small spotty segments throughout the entire left-ventricular myocardium. The regional washout half-times varied between 15.1 and 116.2 min. It seems that in patients with severe COCM the elimination half-times are more prolonged than in early stages of the disease. There was no correlation between the regional uptake and the elimination half-times. Sequential myocardial imaging with I-123 HA appears useful for noninvasively diagnosis of COCM.
AuthorsA Höck, C Freundlieb, K Vyska, B Lösse, R Erbel, L E Feinendegen
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 24 Issue 1 Pg. 22-8 (Jan 1983) ISSN: 0161-5505 [Print] United States
PMID6848699 (Publication Type: Journal Article)
Chemical References
  • Fatty Acids
  • Iodine Radioisotopes
  • 17-iodoheptadecanoic acid
Topics
  • Cardiomyopathies (diagnostic imaging, metabolism)
  • Coronary Disease (diagnostic imaging)
  • Diastole
  • Fatty Acids (metabolism)
  • Half-Life
  • Heart (diagnostic imaging)
  • Heart Septum (metabolism)
  • Heart Ventricles (diagnostic imaging, metabolism, physiopathology)
  • Humans
  • Iodine Radioisotopes
  • Myocardium (metabolism)
  • Radionuclide Imaging

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