Urinary catecholamine metabolites and effects of clonidine in patients with alcohol amnestic disorder.

Abstract

Seven normotensive patients with alcohol amnestic disorder were treated with 2 micrograms/kg clonidine (C) three times daily for 1 wk. Four patients received 12 micrograms/kg/day during the subsequent week; three developed hypotensive symptoms at this dose and remained on 6 micrograms/kg/day. During a predrug placebo period and after 60 hr on each dose of C, urinary excretion rates of catecholamine metabolites were determined. C, 6 micrograms/kg/day, reduced the ratio of norepinephrine (NE) metabolites (mumol/24 hr) to normetanephrine (NM), vanillylmandelic acid (VMA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG). The excretion of metanephrine (M) was not reduced significantly. The ratio M/NM and M/(VMA + MHPG) increased, indicating Cs effects are primarily noradrenergic. Reduction in NM/(VMA + MHPG) indicates disproportionate lowering of the O-methylated metabolite of NE compared to its deaminated metabolites, consistent with C inhibition of NE release. Patients with the highest predrug NM excretion had the greatest decrements with C. The dopamine metabolites 3-methoxytyramine and homovanillic acid were not decreased by C. C-induced reductions in the ratio NM/(VMA + MHPG), an index of NE release, correlated (n = 7) with reductions in supine systolic blood pressure, mean arterial pressure, and salivary flow rate.

• Authors: P R Martin, M H Ebert, E K Gordon, I J Kopin
• Journal: Clinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 33 Issue 1 Pg. 19-27 (Jan 1983) ISSN: 0009-9236 [Print] United States
• PMID: 6848295 (Publication Type: Journal Article)

Chemical References

• Catecholamines
• Clonidine

Topics

• Aged
• Alcohol Amnestic Disorder (drug therapy)
• Blood Pressure (drug effects)
• Catecholamines (urine)
• Clonidine (adverse effects, pharmacology, therapeutic use)
• Dose-Response Relationship, Drug
• Heart Rate (drug effects)
• Humans
• Male
• Middle Aged