Clinical and laboratory evaluation of a commercial kit for measurement of serum free thyroxin ("Amerlex Free T4").

Abstract

Different indexes of thyroid function were determined in conjunction with values obtained with a new commercial radioimmunoassay kit for serum free thyroxin, in 49 apparently healthy subjects, 87 pregnant women, and 142 outpatients attending the thyroid clinic. The results indicate a diagnostic success rate of 88% when free thyroxin was measured instead of estimating the so-called free thyroxin index. Furthermore, in three cases of papillary carcinoma the concentration of free thyroxin was increased, although all the other laboratory tests indicated a euthyroid state. Technically, the method is simple, rapid, and precise, and it would be of most value in the small hospital laboratory lacking the facilities of a comprehensive thyroid-function test service.

• Authors: M Nasralla, M Hassan, A A Al-Ansari, M Kutob, A Al-Abdul Razak, M A Al-Awqati
• Journal: Clinical chemistry (Clin Chem) Vol. 29 Issue 1 Pg. 164-6 (Jan 1983) ISSN: 0009-9147 [Print] England
• PMID: 6848256 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Reagent Kits, Diagnostic
• Thyroxine

Topics

• Adolescent
• Adult
• Aged
• Binding Sites
• Carcinoma, Papillary (blood)
• Evaluation Studies as Topic
• Female
• Humans
• Middle Aged
• Pregnancy
• Radioimmunoassay
• Reagent Kits, Diagnostic
• Thyroid Diseases (blood)
• Thyroxine (blood)