Classical syndromes in occupational medicine: dimethylaminopropionitrile.

Abstract

Dimethylaminopropionitrile, used as a catalyst in the manufacture of polyurethane, was responsible for two epidemics of urinary retention, sexual dysfunction, and peripheral neuropathy in 1978. Most affected workers recovered promptly, but some have had persisting neuropathy, sexual and bladder dysfunction, and CNS symptoms. The mechanism of neurotoxicity appears to be interference with axoplasmic transport. The catalyst that caused the problem was withdrawn from the market after swift governmental action.

• Authors: J P Keogh
• Journal: American journal of industrial medicine (Am J Ind Med) Vol. 4 Issue 3 Pg. 479-89 ( 1983) ISSN: 0271-3586 [Print] United States
• PMID: 6846342 (Publication Type: Journal Article)

Chemical References

• Aminopropionitrile
• dimethylaminopropionitrile

Topics

• Aminopropionitrile (analogs & derivatives, poisoning)
• Animals
• Female
• Government Agencies
• Humans
• Male
• Maryland
• Massachusetts
• Occupational Diseases (chemically induced)
• Rats
• United States
• Urination Disorders (chemically induced)