| Abstract | The hemodynamic effects of a fixed dose of 10 mg i.v. Labetalol were evaluated in 9 CAD patients during a surgical procedure for myocardial revascularisation. The results show a significant mean decrease in heart rate (HR) (-13%), systolic blood pressure (SBP) (-16%) and rate pressure product (RPP) (-28%). Other hemodynamic parameters were not significantly affected. These results were confirmed by a clinical study where in a series of 110 CAD patients 21 were treated during the surgical procedure with incremental doses of Labetalol to control high systolic blood pressure and tachycardia. Administration of a mean dose of 24.3 mg of Labetalol resulted in a significant decrease of RPP (-38%). No side effects related to Labetalol were encountered. |
| Authors | K Joucken |
| Journal | Acta anaesthesiologica Belgica
(Acta Anaesthesiol Belg)
Vol. 34
Issue 1
Pg. 15-26
( 1983)
ISSN: 0001-5164 BELGIUM |
| PMID | 6845955
(Publication Type: Journal Article)
|
| Chemical References |
|
| Topics |
- Aged
- Blood Pressure
(drug effects)
- Coronary Disease
(surgery)
- Ethanolamines
(pharmacology)
- Female
- Heart Rate
(drug effects)
- Hemodynamics
(drug effects)
- Humans
- Infusions, Parenteral
- Labetalol
(administration & dosage, pharmacology)
- Male
- Middle Aged
- Myocardial Revascularization
- Myocardium
(metabolism)
- Oxygen Consumption
(drug effects)
|
