Colorectal carcinomas have a characteristic ganglioside pattern.

Abstract

The gangliosides in six colorectal and two pancreatic carcinomas were examined. Their concentration in the primary tumour and the metastases was 5-10 fold higher than in normal colon mucosa. This increase involved the simple gangliosides, GM3 and GD3, as well as complex mono- and disialogangliosides. Some complex monosialogangliosides were detected in all the colorectal and pancreatic carcinomas but neither in normal colon mucosa and pancreas nor in kidney and lung carcinomas.

• Authors: P Fredman, O Nilsson, L Svennerholm, H Myrvold, B Persson, S Pettersson, J Holmgren, L Lindholm
• Journal: Medical biology (Med Biol) Vol. 61 Issue 1 Pg. 45-8 (Feb 1983) ISSN: 0302-2137 [Print] Finland
• PMID: 6843189 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• G(M3) Ganglioside
• Gangliosides
• ganglioside, GD3

Topics

• Aged
• Colon
• Colonic Neoplasms (analysis)
• Female
• G(M3) Ganglioside (analysis)
• Gangliosides (analysis)
• Humans
• Intestinal Mucosa (analysis)
• Kidney Neoplasms (analysis)
• Liver Neoplasms (secondary)
• Lung Neoplasms (analysis)
• Male
• Middle Aged
• Pancreatic Neoplasms (analysis)
• Rectal Neoplasms (analysis)