Activation of macrophages by quinonyl-N-acetylmuramyl dipeptide.

Abstract

The effect of 6-O-QS-10-N-acetylmuramyl-L-valyl-D-isoglutamine methyl ester (quinonyl-MDP-66) on various functions of macrophages was examined. Mouse peritoneal macrophages, when treated either in vitro or in vivo with quinonyl-MDP-66 suspended in phosphate-buffered saline, showed a capacity for cytolysis and cytostasis against tumor targets and released H2O2 in the presence of phorbol myristate acetate. The macrophages induced by quinonyl-MDP-66 also had both antibody-dependent cell-mediated cytotoxicity and phagocytic activity against erythroid targets. The fact that synthetic quinonyl-MDP-66 stimulates the macrophages to become more cytotoxic than do other MDP analogs suggests that the lipophilic residue (QS-10) in quinonyl-MDP-66 may be important for the development of this activity.

• Authors: I Saiki, Y Tokushima, K Nishimura, Y Yamamura, I Azuma
• Journal: Infection and immunity (Infect Immun) Vol. 40 Issue 2 Pg. 622-8 (May 1983) ISSN: 0019-9567 [Print] United States
• PMID: 6840857 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetylmuramyl-Alanyl-Isoglutamine
• quinonyl-MDP-66
• Hydrogen Peroxide

Topics

• Acetylmuramyl-Alanyl-Isoglutamine (analogs & derivatives, immunology, pharmacology)
• Animals
• Antibody-Dependent Cell Cytotoxicity (drug effects)
• Cells, Cultured
• Cytotoxicity, Immunologic (drug effects)
• Female
• Hydrogen Peroxide (biosynthesis)
• Macrophage Activation
• Macrophages (immunology)
• Mice
• Phagocytosis (drug effects)