| Abstract | A total of 80 subjects with benign and malignant breast disease and healthy controls were studied for reactivity to T-antigen, MN-antigens and phytohemagglutinin (PHA) using the lymphocyte blastogenesis assay. No differences were detected between controls and patients with benign or malignant breast disease in reactivity to T- and MN-antigens. Moreover, there was no differential response to T- and MN-antigens among patients with breast cancer. PHA reactivity, although similar between groups as a whole, was diminished in patients with advanced carcinoma. These findings indicate that T-antigen fails to induce cell mediated immunity in patients with breast cancer. |
| Authors | D R Howard |
| Journal | Cancer
(Cancer)
Vol. 51
Issue 11
Pg. 2053-6
(Jun 1 1983)
ISSN: 0008-543X UNITED STATES |
| PMID | 6839295
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
| Chemical References |
- Antigens, Neoplasm
- MNSs Blood-Group System
- Phytohemagglutinins
|
| Topics |
- Adult
- Antigens, Neoplasm
(immunology)
- Breast Neoplasms
(immunology)
- Female
- Humans
- Immunity, Cellular
- Lymphocyte Activation
- MNSs Blood-Group System
(immunology)
- Middle Aged
- Phytohemagglutinins
(pharmacology)
|
