Reversible obesity and plasma fat metabolites.

Abstract

Rats were made to overeat and gain weight (about 50 g) by long-acting protamine zinc insulin (PZI) treatment. When the PZI treatment was stopped, the rats ate much less than normal for at least seven days. During recovery from PZI-induced obesity, negative correlations were observed between food intake and plasma levels of the fat metabolites, free fatty acids, glycerol, and ketone bodies. A similar but smaller effect was observed during recovery from dietary obesity (about 15 g). The plasma fat metabolites may be the blood-borne signals which suppress hunger under these conditions.

• Authors: R G Carpenter, S P Grossman
• Journal: Physiology & behavior (Physiol Behav) Vol. 30 Issue 1 Pg. 51-5 (Jan 1983) ISSN: 0031-9384 [Print] United States
• PMID: 6836044 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Fatty Acids, Nonesterified
• Insulin, Long-Acting
• Ketone Bodies
• Lipids
• Glycerol

Topics

• Animals
• Body Weight (drug effects)
• Eating (drug effects)
• Fatty Acids, Nonesterified (blood)
• Glycerol (blood)
• Insulin, Long-Acting (pharmacology)
• Ketone Bodies (blood)
• Lipids (blood)
• Lipolysis (drug effects)
• Male
• Rats
• Rats, Inbred Strains