The effect of dihydroxydibutylether on bile lipid composition in patients with gallstones.

Abstract

Dihydroxydibutylether (DHBE, 900 mg/day, in divided doses) was given to 13 patients with radiolucent gallstones. Bile lipid composition and bile saturation were studied before treatment and after 1 and 2 months of therapy. Bile was collected by duodenal intubation (after cerulein-induced gallbladder contraction) in each patient, and biliary lipids were estimated with standard laboratory techniques. The results of this study showed that DHBE treatment was associated with a significant (p less than 0.01) reduction of bile saturation with cholesterol (saturation index: 1.37 +/- 0.39 before treatment, 1.14 +/- 0.35 after 1 month, and 1.08 +/- 0.29 after 2 months). The possible mechanism of this effect and the clinical relevance are discussed.

• Authors: M Ponz de Leon, P Loria, R Iori, I Piccagli, N Carulli, A Belvisi, M Matergi
• Journal: International journal of clinical pharmacology, therapy, and toxicology (Int J Clin Pharmacol Ther Toxicol) Vol. 21 Issue 1 Pg. 37-40 (Jan 1983) ISSN: 0174-4879 [Print] Germany
• PMID: 6832865 (Publication Type: Journal Article)

Chemical References

• Cholagogues and Choleretics
• Ethers
• Lipids
• 4,4'-oxydi-2-butanol

Topics

• Adult
• Aged
• Bile (analysis, drug effects)
• Cholagogues and Choleretics (pharmacology)
• Cholelithiasis (drug therapy, metabolism)
• Ethers (pharmacology, therapeutic use)
• Female
• Humans
• Lipids (analysis)
• Male
• Middle Aged