Effect of diltiazem on recurrent spontaneous angina after acute myocardial infarction.

This study examined the effects of diltiazem, a calcium antagonist, on suppressing spontaneous angina following acute myocardial infarction. Twelve patients developed rest angina within a few days after the onset of acute myocardial infarction, which was associated with transient S-T segment elevation. A 24-hour recording of electrocardiogram revealed cyclic S-T segment elevation with or without chest pain in all patients. A selective coronary arteriography was performed in seven patients which demonstrated no critical stenosis, despite acute myocardial infarction, in three patients. In one of these three patients, coronary artery spasm was induced by ergonovine in the vessel supplying the acutely infarcted area. These clinical features suggested that spontaneous angina in these patients probably was caused by spasm of the coronary artery. Diltiazem suppressed rest angina as well as painless cyclic S-T segment elevation completely in all 12 patients. The replacement of diltiazem with placebo in two patients caused the recurrence of rest angina. Thus, we conclude that diltiazem is effective in the treatment of postinfarction angina caused by coronary artery spasm.
AuthorsM Nakamura, Y Koiwaya
JournalCirculation research (Circ Res) Vol. 52 Issue 2 Pt 2 Pg. I158-62 (Feb 1983) ISSN: 0009-7330 [Print] UNITED STATES
PMID6831648 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Benzazepines
  • Calcium Channel Blockers
  • Diltiazem
  • Aged
  • Angina Pectoris (drug therapy)
  • Benzazepines (therapeutic use)
  • Calcium Channel Blockers (therapeutic use)
  • Coronary Vasospasm (complications)
  • Diltiazem (adverse effects, therapeutic use)
  • Electrocardiography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction (complications)
  • Recurrence

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