Persistent Strongyloides stercoralis in a blind loop of the bowel. Successful treatment with mebendazole.

Abstract

Three courses of thiabendazole therapy, including one course given directly into a blind loop of the bowel, failed to eradicate Strongyloides stercoralis from a 55-year-old man who had undergone a Roux-en-Y operation. The patient responded to 1.5 g/day of mebendazole for 14 days, and the infection did not recur. Our case illustrates the difficulty of eliminating S stercoralis from a blind loop of the bowel and indicates that mebendazole therapy used in adequate doses is effective treatment for strongyloidiasis. The lack of toxicity of mebendazole makes it a desirable drug for Strongyloides infestation resistant to thiabendazole therapy.

• Authors: K H Wilson, C A Kauffman
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 143 Issue 2 Pg. 357-8 (Feb 1983) ISSN: 0003-9926 [Print] United States
• PMID: 6824404 (Publication Type: Case Reports, Journal Article)

Chemical References

• Benzimidazoles
• Mebendazole
• Thiabendazole

Topics

• Benzimidazoles (therapeutic use)
• Drug Resistance, Microbial
• Humans
• Intestinal Diseases, Parasitic (drug therapy)
• Male
• Mebendazole (therapeutic use)
• Middle Aged
• Peptic Ulcer (surgery)
• Strongyloidiasis (drug therapy)
• Thiabendazole (therapeutic use)