Z-DNA-specific antibodies in human systemic lupus erythematosus.

Abstract

Naturally occurring antibodies to left-handed Z-DNA have been shown to be present in the sera of human patients with systemic lupus erythematosus (SLE). These antibodies are of two types. One type reacts with both denatured DNA and Z-DNA. The other type is specific for Z-DNA and remained in the serum after removal of the cross-reactive antibody by extensive absorption on a denatured DNA affinity column. The antibodies appear to be specific for SLE and do not appear frequently in other rheumatic diseases. The presence of the antibody in SLE is correlated with the clinical manifestations of the disease, in parallel with antibodies to native and denatured DNA.

• Authors: E M Lafer, R P Valle, A Möller, A Nordheim, P H Schur, A Rich, B D Stollar
• Journal: The Journal of clinical investigation (J Clin Invest) Vol. 71 Issue 2 Pg. 314-21 (Feb 1983) ISSN: 0021-9738 [Print] United States
• PMID: 6822666 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Autoantibodies
• DNA

Topics

• Antibody Specificity
• Autoantibodies (classification, isolation & purification)
• Chromatography, Agarose
• DNA (immunology)
• Humans
• Lupus Erythematosus, Systemic (immunology)
• Nucleic Acid Conformation
• Osmolar Concentration
• Radioimmunoassay