Seventh nerve spasm: effect of modification of cholinergic balance.

Abstract	The seventh cranial nerve spasms of the face and the eyelids, including essential blepharospasm, are usually intractable and sometimes disabling. Deanol acetamidobenzoate was compared with the anticholinergic orphenadrine for relief of these spasms. Deanol cured two of 16 (12%) subjects and improved a third. Orphenadrine was much more effective, improving the conditions of 16 of 26 (62%) subjects between 57% and 100%. A crossover double-blind experiment showed high significance over a placebo.
Authors	E C Hughes, D E Brackmann, R C Weinstein
Journal	Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (Otolaryngol Head Neck Surg) 1980 Jul-Aug Vol. 88 Issue 4 Pg. 491-9 ISSN: 0194-5998 [Print] England
PMID	6821438 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References	Ethanolamines Deanol Orphenadrine
Topics	Adult Aged Blepharospasm (drug therapy) Deanol (therapeutic use) Double-Blind Method Drug Evaluation Ethanolamines (therapeutic use) Facial Muscles (innervation) Facial Nerve Female Humans Male Middle Aged Orphenadrine (therapeutic use) Random Allocation Spasm (drug therapy)

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