Preclinical ocular evaluation of noncorticosteroidal antiinflammatory agents.

Abstract

The nature of inflammation in general and the special aspects of ocular inflammation are discussed. Causes of inflammation, the cellular and tissue response to noxious stimuli and the biochemical mediation of the inflammatory response are described. Prostaglandins and their relatives the thromboxanes and prostacyclins are shown to play an important role in the mediation of ocular inflammation. Inhibitors of the biochemical synthesis of prostaglandins show strong potential for use in topical ocular antiinflammatory therapy, however their preclinical evaluation requires the choice of a suitable animal model. A review of animals of both specific and general ocular inflammation is presented.

• Authors: D L Murray, I H Leopold
• Journal: Metabolic, pediatric, and systemic ophthalmology (Metab Pediatr Syst Ophthalmol) Vol. 6 Issue 3-4 Pg. 201-8 ( 1982) ISSN: 0277-9382 [Print] United States
• PMID: 6820959 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents
• Prostaglandin Antagonists
• Prostaglandins

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Antigen-Antibody Reactions
• Autoimmune Diseases (immunology)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Endophthalmitis (drug therapy, etiology, immunology)
• Guinea Pigs
• Haplorhini
• Immunity, Cellular
• Methods
• Phagocytosis
• Prostaglandin Antagonists (therapeutic use)
• Prostaglandins (physiology)
• Rabbits