Ga-67 and Fe-59 distributions in mice.

Abstract

Tissue distributions of i.v.-injected Ga-67 citrate and [59Fe] ferric citrate were measured in normal mice and in lymphoid-tumor hosts. The study arose out of previously reported tissue-culture work showing marked transferrin stimulation of Ga-67 and Fe-59 uptakes by cultured cells from mouse lymphoid tumors. In vivo, however, no obvious correlation was found between Ga-67 and Fe-59 tissue distributions; indeed, Ga-67 showed high affinity for tumor tissue and low affinity for hemopoietic tissues, while for Fe-59 the reverse applied. Taken together, these comparisons of kinetics and distributions for Ga-67 and Fe-59 suggest that a tissue's avidity for Ga-67 is strongly influenced by other factors besides the cell population's capacity for transferrin interactions.

• Authors: R G Sephton, G S Hodgson, S De Abrew, A W Harris
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 19 Issue 8 Pg. 930-5 (Aug 1978) ISSN: 0161-5505 [Print] United States
• PMID: 682025 (Publication Type: Journal Article)

Chemical References

• Citrates
• Ferric Compounds
• Gallium Radioisotopes
• Iron Radioisotopes

Topics

• Aging
• Animals
• Citrates (administration & dosage, metabolism)
• Ferric Compounds (administration & dosage, metabolism)
• Gallium Radioisotopes (administration & dosage, metabolism)
• Injections, Intravenous
• Iron Radioisotopes (administration & dosage, metabolism)
• Lymphoma (metabolism)
• Mice
• Neoplasms, Experimental (metabolism)
• Tissue Distribution