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3,3'-Iminodipropionitrile induced centrifugal segmental demyelination and onion bulb formation.

Abstract
Centrifugal segmental demyelination extended from the proximal to the distal portion, and onion bulb formation in the extraspinal ventral root occurred following the axonal lesion of the intraspinal ventral root induced by 3,3'-iminodipropionitrile. These results suggest that axonal factors may be responsible to segmental demyelination and onion bulb formation.
AuthorsM Shimono, K Izumi, V Kuroiwa
JournalJournal of neuropathology and experimental neurology (J Neuropathol Exp Neurol) 1978 Jul-Aug Vol. 37 Issue 4 Pg. 375-86 ISSN: 0022-3069 [Print] England
PMID681981 (Publication Type: Journal Article)
Chemical References
  • Nitriles
  • 3,3'-iminodipropionitrile
Topics
  • Animals
  • Axons (ultrastructure)
  • Demyelinating Diseases (chemically induced, pathology)
  • Male
  • Nerve Fibers, Myelinated (ultrastructure)
  • Nitriles
  • Rats
  • Spinal Nerve Roots (pathology)

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