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[Exudative enteropathy caused by clofazimine: apropos of a case].

Abstract
The authors report a case of a forty-six year old woman suffering from generalized prurigo nodularis. This dermatosis was associated with a cellular immunodeficiency; therefore a clofazimine therapy 300 mg/a day was instituted for six months. Ten months after the cessation of the clofazimine therapy, there appeared a malabsorption syndrome that was temporarily improved by gluten--free diet the real etiology was only ascertained during laparotomy, when masses of crystals in the small intestine mucosa as well as in mesenteric lymph nodes were observed. Therefore when it is necessary to prescribe clofazimine to take advantage of become its immunoregulating properties, it must always become in mind that an intestinal complication may ensue: this is well recognized in articles appearing in journals devoted to leprosy.
AuthorsP Belaube, J Devaux, R Boutboul, C de Micco, M Pizzi, Y Privat
JournalActa leprologica (Acta Leprol) 1982 Jul-Sep Issue 88 Pg. 61-7 ISSN: 0001-5938 [Print] Switzerland
Vernacular TitleEntéropathie exsudative à la clofazimine: à propos d'une observation.
PMID6818819 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Clofazimine
Topics
  • Clofazimine (adverse effects, analysis)
  • Crystallization
  • Female
  • Humans
  • Intestinal Diseases (chemically induced, metabolism)
  • Intestinal Mucosa (analysis)
  • Lymph Nodes (analysis)
  • Middle Aged
  • Prurigo (drug therapy)

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