A placebo controlled study of the cardiovascular effects of fluvoxamine and clovoxamine in human volunteers.

Abstract

1 Fluvoxamine and clovoxamine, two new potential antidepressants were given to 27 healthy male volunteers in a double-blind, placebo controlled, three-way crossover study. 2 Neither compound affected the electrical intervals of 24 h ambulant electrocardiographic monitoring with the exception of a small increase in R-R interval. 3 There were no changes in blood pressure measurements. 4 The only notable unwanted symptom was nausea for both fluvoxamine and clovoxamine.

• Authors: J F Robinson, D P Doogan
• Journal: British journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 14 Issue 6 Pg. 805-8 (Dec 1982) ISSN: 0306-5251 [Print] England
• PMID: 6817771 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Antidepressive Agents
• Oximes
• Placebos
• clovoxamine
• Fluvoxamine

Topics

• Antidepressive Agents (adverse effects, pharmacology)
• Blood Pressure (drug effects)
• Fluvoxamine
• Heart Rate (drug effects)
• Hemodynamics (drug effects)
• Humans
• Male
• Middle Aged
• Oximes (adverse effects, pharmacology)
• Placebos
• Time Factors