Xanthone-2-carboxylic acid effect on lens growth, hydration and proteins during diabetic cataract development.
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| Abstract |
The concomitant protective effects of the aldose reductase inhibitor, 7-dimethylsulfamoyl-xanthone-2-carboxylic acid, were established by three lens parameters (soluble crystallin proteins, growth and cell hydration) because their quantitation provided a comprehensive index of lens physiology during sugar cataractogenesis in the rat neonate. Their fused eyelids provided the orbital pouch for topical administration of inhibitor to the treated lens; the contralateral pouch served as an untreated control. Protein preservation was determined by gel filtration chromatography. In galactose-maintained neonates, untreated lenses exhibited only 50% of the normal Fraction II protein whereas xanthone-treatment maintained 73% of this component. Quantitative analysis of scanning electron micrographs indicated that xanthone-treatment partially protected lenses against both intra and extracellular fluid accumulation as determined by measurements of individual fiber cell thickness, density (the number of cells/10 micron cortex), and interdigitation. In addition, xanthone-treatment improved lens growth as evidenced by radius and dry weight measurements. Our results suggest that topically applied xanthone partially inhibited sugar cataractogenesis.
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| Authors | A Beyer-Mears, E Cruz, J Nicolas-Alexandre, E Varagiannis |
| Journal | Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 259 Issue 1 Pg. 166-76 (Sep 1982) ISSN: 0003-9780 [Print] Belgium |
| PMID | 6817723 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.) |
| Chemical References |
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