Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.

Abstract

Colonic tumors were induced in male Sprague-Dawley rats by ten applications of 2 mg/kg/week N-nitrosoacetoxymethyl-methylamine (AMMN) or by three applications of 100 mg/kg/month 1,2-dimethylhydrazine (1,2-DMH). Application of AMMN and 1,2-DMH induced selective colonic tumors in 97% and 29-42% of the initial animals, respectively. Colonic-tumor-bearing animals were subjected to monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A. No cures were achieved. The different therapies did not exert any clear influence on the survival time of animals, except for animals pretreated with AMMN and then subjected to ftorafur therapy.

• Authors: I Wagner, M Habs, D Schmähl, H Amberger, U Bachmann
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 104 Issue 1-2 Pg. 115-31 ( 1982) ISSN: 0171-5216 [Print] Germany
• PMID: 6813336 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Carcinogens
• Dimethylhydrazines
• Methylhydrazines
• Nitrosourea Compounds
• Phenylurea Compounds
• Tegafur
• 1-(2-(2-(4-pyridyl)-2-imidazoline-1-yl)ethyl)-3-(4-carboxyphenyl)urea
• methyl(acetoxymethyl)nitrosamine
• CGP 6809
• 1,2-Dimethylhydrazine
• Dimethylnitrosamine
• Fluorouracil

Topics

• 1,2-Dimethylhydrazine
• Animals
• Antineoplastic Agents (therapeutic use)
• Carcinogens
• Colonic Neoplasms (chemically induced, drug therapy)
• Dimethylhydrazines
• Dimethylnitrosamine (analogs & derivatives)
• Fluorouracil (analogs & derivatives, therapeutic use)
• Male
• Methylhydrazines
• Neoplasms, Experimental (drug therapy)
• Nitrosourea Compounds
• Phenylurea Compounds (therapeutic use)
• Rats
• Rats, Inbred Strains
• Tegafur (therapeutic use)