Abstract |
A new variant of G6PD associated with chronic nonspherocytic hemolytic anemia (CNSHA) in a Japanese male is described. This variant is unique in that it has a normal electrophoretic mobility, normal Km for glucose-6-phosphate and NADP, and a normal utilization of the substrate 2-deoxyglucose-6-phosphate and deamino- NADP. It also shows a decreased thermal stability and a biphasic pH curve. These characteristics distinguish this variant from previously reported variants associated with CNSHA and we have called it G6PD Kanazawa.
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Authors | T Kitao, K Ito, K Hattori, T Matsuki, Y Yoneyama |
Journal | Acta haematologica
(Acta Haematol)
Vol. 68
Issue 2
Pg. 131-5
( 1982)
ISSN: 0001-5792 [Print] Switzerland |
PMID | 6812368
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Glucosephosphate Dehydrogenase
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Topics |
- Adult
- Anemia, Hemolytic, Congenital
(complications)
- Anemia, Hemolytic, Congenital Nonspherocytic
(complications, enzymology, genetics)
- Glucosephosphate Dehydrogenase
(analysis, genetics)
- Glucosephosphate Dehydrogenase Deficiency
(blood, complications, genetics)
- Humans
- Hydrogen-Ion Concentration
- Japan
- Male
- Pedigree
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