Abstract |
Humoral immune responses to alloantigens on P815 mastocytoma cells placed into the anterior chamber of murine eyes were studied. The results show that: (1) the amount of specific serum antibody produced by recipients of intracamerally injected P815 cells is directly proportional to the degree of immunogenetic disparity between the recipient and the injected cells; (2) destruction of allogeneic intraocular tumors is mediated, at least in part, by specific antibodies; and (3) retention of allogeneic tissue within the anterior chamber for 3 to 4 days after inoculation is essential to the elicitation of specific antibody formation. We conclude that alloantigens introduced into the anterior chamber are presented to the systemic immune apparatus in a very unique manner resulting in the preferential stimulation of specific antibody production without awakening specific cell-mediated immunity.
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Authors | J Y Niederkorn, J W Streilein |
Journal | Transplantation
(Transplantation)
Vol. 33
Issue 6
Pg. 573-7
(Jun 1982)
ISSN: 0041-1337 [Print] United States |
PMID | 6808721
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- H-2 Antigens
- Isoantibodies
- anti-H-2 antibodies
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Topics |
- Animals
- Anterior Chamber
- Eye Neoplasms
(immunology)
- Female
- Graft Survival
- H-2 Antigens
(administration & dosage, genetics, immunology)
- Injections, Intravenous
- Isoantibodies
(biosynthesis)
- Mast-Cell Sarcoma
(immunology)
- Mice
- Mice, Inbred A
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Neoplasm Transplantation
- Skin Transplantation
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