Valproic acid in the treatment of intractable absence seizures in children: a single-blind clinical and quantitative EEG study.

Abstract

A 12-week single-blind study used valproic acid in the treatment of refractory, simple and complex absence (petit mal) seizures in 17 children. The clinical seizure control was compared with the number and duration of electrical discharges on six-hour EEG recordings before and during therapy. Sixteen patients showed clinical improvement. Fourteen had greater than 75% clinical improvement and ten patients became free of absence seizures. Side effects were mild, but two patients experienced transient, asymptomatic thrombocytopenia. Good correlation between clinical response and decreasing seizure activity on the EEG occurred in the seizure-free patients.

• Authors: G Erenberg, A D Rothner, C E Henry, R P Cruse
• Journal: American journal of diseases of children (1960) (Am J Dis Child) Vol. 136 Issue 6 Pg. 526-9 (Jun 1982) ISSN: 0002-922X [Print] United States
• PMID: 6807081 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticonvulsants
• Valproic Acid

Topics

• Adolescent
• Anticonvulsants (therapeutic use)
• Blood Platelet Disorders (chemically induced)
• Child
• Child, Preschool
• Clinical Trials as Topic
• Drug Interactions
• Electroencephalography
• Epilepsy, Absence (drug therapy, physiopathology)
• Female
• Humans
• Male
• Valproic Acid (adverse effects, therapeutic use)