Comparison of the mutagenic potency of 2-chloroethanol, 2-bromoethanol, 1,2-epoxybutane, epichlorohydrin and glycidaldehyde in Klebsiella pneumoniae, Drosophila melanogaster and L5178Y mouse lymphoma cells.

Abstract

A series of 2 haloethanols and 3 epoxides was investigated in 3 mutagenicity test systems, namely (1) the fluctuation test in Klebsiella pneumoniae, (2) the sex-linked recessive lethal test in Drosophila melanogaster, and (3) the HGPRT test with L5178Y mouse lymphoma cells. The order of mutagenic potency was, in Klebsiella: glycidaldehyde greater than 2-bromoethanol = epichlorohydrin greater than 1,2-epoxybutane greater than 2-chloroethanol; in Drosophila: glycidaldehyde = epichlorohydrin greater than 1,2-epoxybutane; in mouse lymphoma cells: epichlorohydrin greater than 1,2-epoxybutane. The haloethanols were non-mutagenic in Drosophila. 2-Chloroethanol and glycidaldehyde were negative in mouse lymphoma cells. The high mutagenic potency of epichlorohydrin as compared with 1,2-epoxybutane was consistent in all systems, and with published data.

• Authors: A G Knaap, C E Voogd, P G Kramers
• Journal: Mutation research (Mutat Res) Vol. 101 Issue 3 Pg. 199-208 (May 1982) ISSN: 0027-5107 [Print] Netherlands
• PMID: 6806641 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Aldehydes
• Chlorohydrins
• Epoxy Compounds
• Ethers, Cyclic
• Mutagens
• Epichlorohydrin
• 1,2-epoxybutane
• Ethanol
• Ethylene Chlorohydrin
• glycinaldehyde
• ethylene bromohydrin

Topics

• Aldehydes (pharmacology)
• Animals
• Chlorohydrins (pharmacology)
• Drosophila melanogaster (drug effects)
• Epichlorohydrin (pharmacology)
• Epoxy Compounds (pharmacology)
• Ethanol (analogs & derivatives, pharmacology)
• Ethers, Cyclic (pharmacology)
• Ethylene Chlorohydrin (pharmacology)
• Female
• Klebsiella pneumoniae (drug effects)
• Leukemia L5178 (genetics)
• Male
• Mice
• Mutagenicity Tests
• Mutagens (pharmacology)