| Abstract | 12 plasmapheresis were carried out in 5 patients with antibodies to F VIII (3 haemaophilic antibodies; 2 spontaneous antibodies). Plasmapheresis led in all instances to a marked reduction of the antibody level there was a good correlation between the amount of plasma exchanged and the decrease of the antibody level. About 40 ml of plasma/kg body weight have to be removed to reduce the antibody level to half. In patients with low titre antibody who need treatment for serious bleeding, plasmapheresis is a more rapid and less expensive procedure than neutralisation of the inhibitor by high doses of F VIII. In one haemophiliac repeated plasmapheresis and subsequent high dose F VIII treatment eliminated the antibody within a short time. Plasmapheresis should always be considered when patients with antibodies to F VIII have to be treated because of severe bleeding. |
| Authors | M Francesconi, C Korninger, E Thaler, H Niessner, P Höcker, K Lechner |
| Journal | Haemostasis
(Haemostasis)
Vol. 11
Issue 2
Pg. 79-86
( 1982)
ISSN: 0301-0147 SWITZERLAND |
| PMID | 6806156
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Antigens
- Blood Coagulation Factors
- Isoantibodies
- von Willebrand Factor
- Factor VIII
|
| Topics |
- Adolescent
- Adult
- Aged
- Antigens
(immunology, therapeutic use)
- Blood Coagulation Factors
(analysis)
- Factor VIII
(immunology, therapeutic use)
- Female
- Hemophilia A
(therapy)
- Humans
- Immunologic Memory
- Isoantibodies
(biosynthesis)
- Male
- Middle Aged
- Plasmapheresis
(adverse effects)
- Platelet Count
- Shivering
- Time Factors
- von Willebrand Factor
|
