Plasmapheresis: its value in the management of patients with antibodies to factor VIII.

Abstract

12 plasmapheresis were carried out in 5 patients with antibodies to F VIII (3 haemaophilic antibodies; 2 spontaneous antibodies). Plasmapheresis led in all instances to a marked reduction of the antibody level there was a good correlation between the amount of plasma exchanged and the decrease of the antibody level. About 40 ml of plasma/kg body weight have to be removed to reduce the antibody level to half. In patients with low titre antibody who need treatment for serious bleeding, plasmapheresis is a more rapid and less expensive procedure than neutralisation of the inhibitor by high doses of F VIII. In one haemophiliac repeated plasmapheresis and subsequent high dose F VIII treatment eliminated the antibody within a short time. Plasmapheresis should always be considered when patients with antibodies to F VIII have to be treated because of severe bleeding.

• Authors: M Francesconi, C Korninger, E Thaler, H Niessner, P Höcker, K Lechner
• Journal: Haemostasis (Haemostasis) Vol. 11 Issue 2 Pg. 79-86 ( 1982) ISSN: 0301-0147 [Print] Switzerland
• PMID: 6806156 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens
• Blood Coagulation Factors
• Isoantibodies
• von Willebrand Factor
• Factor VIII

Topics

• Adolescent
• Adult
• Aged
• Antigens (immunology, therapeutic use)
• Blood Coagulation Factors (analysis)
• Factor VIII (immunology, therapeutic use)
• Female
• Hemophilia A (therapy)
• Humans
• Immunologic Memory
• Isoantibodies (biosynthesis)
• Male
• Middle Aged
• Plasmapheresis (adverse effects)
• Platelet Count
• Shivering
• Time Factors
• von Willebrand Factor