Abstract |
Acquired resistance to facultative intracellular bacteria depends on two interacting classes of cells: antigen specific T lymphocytes and mononuclear phagocytes. After specific interaction with antigen, T lymphocytes are capable of activating mononuclear phagocytes to form granulomas and to acquire enhanced bacteriocidal capacity. In general, protection is paralleled by delayed hypersensitivity to bacterial antigens. Although Robert Koch had already postulated that protection against Mycobacterium tuberculosis and delayed hypersensitivity to tuberculin in principle depend on an identical mechanism, this question has been unresolved thus far. Recently it has become possible (a) to select heterogeneous T cell subpopulations by serologic methods and (b) to clone and propagate homogeneous T cell lines in a biologically active form. Applying these techniques, we could show that a single T cell population specific for the intracellular bacterium, Listeria monocytogenes, is capable of mediating both antibacterial protection and delayed hypersensitivity. These data show that both functions in principle depend on an identical mechanism thus resolving the problem in Robert Koch's original sense.
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Authors | S H Kaufmann, H Hahn |
Journal | Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...
(Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol)
Vol. 251
Issue 3
Pg. 369-79
(Mar 1982)
ISSN: 0174-3031 [Print] Germany |
Vernacular Title | Infektabwehr gegen fakultativ intrazelluläre Bakterien: Zur Frage nach der Identität der Schutz und verzögerte Allergie vermittelnden Zelle. |
PMID | 6805155
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Topics |
- Bacteria
(immunology)
- Humans
- Hypersensitivity, Delayed
- Immunity, Cellular
- Monocytes
(immunology)
- Mycobacterium tuberculosis
(immunology)
- Phagocytosis
- Species Specificity
- T-Lymphocytes
(immunology)
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